Datasets

Working with functions and splines

How to represent your time-course data with functions and work with them.

create_moanin_model(<DataFrame>) create_moanin_model(<data.frame>) create_moanin_model(<matrix>) create_moanin_model(<SummarizedExperiment>)

Class Moanin

fit_splines()

Fit splines to each gene of data matrix

fit_predict_splines()

Get fitted values for splines for each gene

plot_splines_data(<Moanin>,<matrix>) plot_splines_data(<Moanin>,<numeric>) plot_splines_data(<Moanin>,<data.frame>) plot_splines_data(<Moanin>,<DataFrame>) plot_splines_data(<Moanin>,<missing>)

Plotting splines

Differential expression analysis on timecourse data

Functions to perform week-by-week and overall differential expression analysis.

DE_timecourse(<Moanin>)

Run spline models and test for DE of contrasts.

DE_timepoints(<Moanin>) create_timepoints_contrasts(<Moanin>)

Fit weekly differential expression analysis

estimate_log_fold_change(<Moanin>)

Estimates log fold change

Clustering

splines_kmeans(<Moanin>)

Performs splines clustering using K-means

splines_kmeans_predict(<Moanin>) splines_kmeans_score_and_label(<Moanin>)

Assign score and labels from raw data

plot_cdf_consensus() get_auc_similarity_scores() plot_model_explorer()

Evaluate the consensus between sets of clusterings

consensus_matrix()

Compute consensus matrix from labels

Downstream analyis

find_enriched_go_terms() create_go_term_mapping()

Find enriched GO terms

Miscellenaous

pvalues_fisher_method()

Fisher's method to combine pvalues

expression_filtering()

Utility function to filter out low-expressed genes